Publications
* Corresponding Author, # Co-first author
Tomomatsu S, Matsuo Y*, Ohtake F, Tomita T, Saeki Y, Inada T*. Polyubiquitin architecture editing on collided ribosomes maintains persistent RQC activity. EMBO J. 2025 Nov;44(21):6051-6077.
Sato N, Nakano Y, Matsuki Y, Tomomatsu S, Li S, Matsuo Y, Inada T*. Crucial roles of Grr1 in splicing and translation ofHAC1 mRNA upon unfolded stress response in yeast. Nat Commun. 16(1):2172. (2025)
Mogi Y#, Matsuo Y#, Kondo Y, Higashiyama T, Inada T, Yoshida Y*. Genome-wide changes of protein translation levels for cell and organelle proliferation in a simple unicellular alga. Proc Jpn Acad Ser B Phys Biol Sci. 101(1):41-53. (2025)
Kim KQ#, Li JJ#, Nanjaraj Urs AN#, Pacheco ME, Lasehinde V, Denk T, Tesina P, Tomomatsu S, Matsuo Y, McDonald E, Beckmann R, Inada T, Green R*, Zaher HS*. Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes. Mol Cell. 84(23):4594-4611.e9. (2024)
Ikeuchi K, Ivic N, Buschauer R, Cheng J, Frohlich T, MatsuoY, Berninghausen O, Inada T, Becker T*, Beckmann R*. Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun. 14(1): 2730. (2023)
Best K, Ikeuchi K, Kater L, Best D, Musial J, Matsuo Y, Berninghausen O, Becker T, Inada T*, Beckmann R*. Structural basis for clearing of ribosome collisions by the RQT complex. Nat Commun. 14(1): 921. (2023)
Tesina P*#, Ebine S#, Buschauer R#, Thoms M, Matsuo Y, Inada T*, Beckmann R*. Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol Cell. 83(4): 607-621. (2023)
Matsuo Y*, Inada T*. Co-translational quality control induced by translational arrest. Biomolecules 13(2), 317. (2023)
Matsuo Y*, Uchihashi T, Inada T*. Decoding of the ubiquitin code for clearance of colliding ribosomes by the RQT complex. Nat Commun. 14(1):79. (2023)
Tomomatsu S#, Watanabe A#, Tesina P, Hashimoto S, Ikeuchi K, Li S, Matsuo Y, Beckmann R, Inada T*. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate No-go decay. Nucleic Acids Res. 51(1):253-270. (2023)
Narita M#, Denk T#, Matsuo Y, Sugiyama T, Kikuguchi C, Ito S, Sato N, Suzuki T, Hashimoto S, Machova I, Tesina P, Beckmann R*,Inada T*. A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. Nat Commun. 13(1):6411. (2022)
Li S#, Ikeuchi K#, Kato M, Buschauer R, Sugiyama T, Adachi S, Kusano H, Natsume T, Berninghausen O, Matsuo Y, Becker T, Beckmann R*, Inada T*. Sensing of individual stalled 80S ribosomes by Fap1 for non-functional rRNA turnover. Mol Cell.82(18):3424-3437. (2022)
Alam M#, Shima H#, Matsuo Y, Long NC, Matsumoto M, Ishii Y, Sato N, Sugiyama T, Nobuta R, Hashimoto S, Liu L, Kaneko MK, Kato Y, Inada T*, Igarashi K*. mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine. J Biol Chem. 298(7): 102084. (2022)
Mita Y, Uchida R, Yasuhara S, Kishi K, Hoshi T, Matsuo Y, Yokooji T, Shirakawa Y, Toyama T, Urano Y, Inada T, Noguchi N, Saito Y*. Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation. Nucleic Acids Res. 49(12):6893-6907. (2021)
Matsuo Y*, Inada T*. The ribosome collision sensor Hel2 functions as preventive quality control in the secretory pathway. Cell Rep. 34(12):108877. (2021)
Takehara Y#, Yashiroda H#, Matsuo Y, Zhao X, Kamigaki A, Matsuzaki T, Kosako H, Inada T, Murata S*. The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation. iScience. 24(3):102145. (2021)
Mizuno M#, Ebine S#, Shounai O, Nakajima S, Tomomatsu S, Ikeuchi K, Matsuo Y, Inada T*. The nascent polypeptide in the 60S subunit determines the Rqc2-dependency of ribosomal quality control. Nucleic Acids Res. gkab005. (2021)
Matsuki Y#, Matsuo Y#, Nakano Y, Iwasaki S, Yoko H, Udagawa T, Li S, Saeki Y, Yoshihisa T, Tanaka K, Ingolia NT, Inada T*. Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome. Sci Rep. 10(1):19669. (2020)
Matsuki Y, Saito T, Nakano Y, Hashimoto S, Matsuo Y, Inada T*. Crucial role of leaky initiation of uORF3 in the downregulation of HNT1 by ER stress. Biochem Biophys Res Commun. 528(1):186-192. (2020)
Buschauer R#, Matsuo Y#, Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Nobuta R, Gilmozzi A, Berninghausen O, Tesina P, Becker T, Coller J*, Inada T*, Beckmann R*. The Ccr4-Not complex monitors the translating ribosome for codon optimality. Science. 368(6488): eaay6912. (2020)
Matsuo Y#, Tesina P#, Nakajima S, Mizuno M, Endo A, Buschauer R, Cheng J, Shounai O, Ikeuchi K, Saeki Y, Becker T, Beckmann R*, Inada T*. RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat Struct Mol Biol. 27(4):323-332. (2020)
Sugiyama T#, Li S#, Kato M#, Ikeuchi K, Ichimura A, Matsuo Y, Inada T*. Sequential Ubiquitination of Ribosomal Protein uS3 Triggers the Degradation of Non-functional 18S rRNA. Cell Rep. 26(12):3400-3415.e7. (2019)
Ikeuchi K#, Tesina P#, Matsuo Y, Sugiyama T, Cheng J, Saeki Y, Tanaka K, Becker T, Beckmann R*, Inada T*. Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways. EMBO J. 38(5):e100276. (2019)
Matsuo Y#, Ikeuchi K#, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T*. Ubiquitination of stalled ribosome triggers ribosome-associated quality control. Nat. Commun.8(1):159. (2017)
Matsuo Y, Granneman S, Thoms M, Manikas RG, Tollervey D, Hurt E*. Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export. Nature. 505(7481):112-116. (2014)
Matsuo Y, Oshima T, Loh PC, Morimoto T, Ogasawara N*. Isolation and characterization of a dominant negative mutant of Bacillus subtilis GTP-binding protein, YlqF, essential for biogenesis and maintenance of the 50S ribosomal subunit. J. Biol. Chem. 282(35):25270-7. (2007)
Loh PC, Morimoto T, Matsuo Y, Oshima T, Ogasawara N*. The GTP-binding protein YqeH participates in biogenesis of the 30S ribosome subunit in Bacillus subtilis. Genes Genet Syst. 82(4):281-9. (2007)
Matsuo Y, Morimoto T, Kuwano M, Loh PC, Oshima T, Ogasawara N*. The GTP-binding protein YlqF participates in the late step of 50S ribosomal subunit assembly in Bacillus subtilis. J. Biol. Chem. 281(12):8110-7. (2006)